About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Colchicine is a microtubulepolymerization inhibitor that binds tubulin, preventing formation of the mitotic spindle. This disrupts neutrophil chemotaxis, inflammasome activation (particularly NLRP3), and cytokine release. Its powerful antiinflammatory activity stems from inhibition of microtubuledependent cell migration and intracellular trafficking.
Benefits and Advantages
Used in goutpathophysiology modelling, tubulinbinding research, inflammasome inhibition studies, mitosisdisruption assays, and autoinflammatorydisease investigations.
Side Effects and Risks
Risks include GI toxicity, myelosuppression, neuromyopathy, hepatotoxicity and multiorgan dysfunction at high concentrations. Handle as a potent tubulindisrupting agent.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C22H25NO6 |
|---|---|
| Molecular Weight | 399.4 g/mol |
| CAS Number | 64-86-8 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | greater than or equal to 100 mg/mL at 70 °F (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | colchicine; 64-86-8; Colchisol; Colchineos; Colchicinum |
| IUPAC/Chemical Name | N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide |
| InChl Key | IAKHMKGGTNLKSZ-INIZCTEOSA-N |
| InChl Code | InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1 |
| References |
3D Conformer.
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