About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
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Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Dobetason propionate is an ultra‑potent topical corticosteroid (class I) that binds cytosolic glucocorticoid receptors (GR), inhibiting NF‑κB, AP‑1 and pro‑inflammatory cytokine transcription. It reduces vasodilation, edema formation, leukocyte migration and epidermal hyperproliferation. Esterification increases dermal penetration, potency and duration of receptor occupancy.
Benefits and Advantages
Used in severe‑psoriasis modelling, dermal‑inflammation research, GR‑receptor signalling assays, keratinocyte‑proliferation inhibition studies and high‑potency corticosteroid SAR analyses.
Side Effects and Risks
Risks include significant skin atrophy, telangiectasia, striae, HPA‑axis suppression, periorificial dermatitis and systemic absorption with prolonged use. Handle with ultra‑potent topical‑steroid precautions.
Datasheet
| Molecular Formula | C26H33FO6 |
|---|---|
| Molecular Weight | 430.53 g/mol |
| CAS Number | 23900-58-5 |
| Storage Condition | Store in a cool, dry place; protect from light |
| Solubility | Soluble in water |
| Purity | Purity information is available upon request (COA). |
| IUPAC/Chemical Name | 11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate |
| InChl Key | Unavailable |
| InChl Code | Unavailable |
| References | PubChem; ChemBL; FDA; |
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