DEHYDROCORTISONE HEMISUCC
Delavirdine mesylate is a nonnucleoside reverse transcriptase inhibitor (NNRTI) that binds HIV1 reverse transcriptase and blocks viral DNA synthesis. It has been used in combination antiretroviral therapy. Side effects include rash, headache, and gastrointestinal upset, with significant drugdrug interaction potential. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
Dehydrocortisone hemisuccinate is a watersoluble ester derivative of dehydrocortisone designed to enhance dissolution and facilitate controlled enzymatic release of the parent corticosteroid. After cleavage of the hemisuccinate ester, the active molecule binds glucocorticoid receptors, suppressing NF-κB and AP1driven transcription and modulating metabolic and immune pathways. Its improved solubility allows consistent distribution in aqueous assay systems.
Benefits and Advantages
Used in glucocorticoidreceptor pathway studies, inflammationsuppression modelling, solublesteroid delivery research, HPAaxis simulations and steroidprodrug activation assays.
Side Effects and Risks
Risks include adrenal suppression, immune impairment, hyperglycemia, fluid retention and possible hepatic stress. Handle with glucocorticoidclass precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C25H32O7 |
|---|---|
| Molecular Weight | 462.53 g/mol |
| CAS Number | 6051-87-2 |
| Storage Condition | Store in a cool, dry place; protect from light |
| Solubility | Soluble in water |
| Purity | Purity information is available upon request (COA). |
| Synonym | beta-naphthoflavone; 6051-87-2; 5,6-BENZOFLAVONE; beta-NF; 3-Phenyl-1H-naphtho(2,1-b)pyran-1-one |
| IUPAC/Chemical Name | Cortisone hemisuccinate ester |
| InChl Key | Unavailable |
| InChl Code | Unavailable |
| References | PubChem; ChemBL; FDA; |
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