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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
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Product Description
Mechanism of Action
Cortisone acetate is a prodrug converted by 11β‑hydroxysteroid dehydrogenase type 1 (11β‑HSD1) into active hydrocortisone. Its mechanism involves GR‑mediated suppression of pro‑inflammatory transcription, inhibition of phospholipase A₂ pathways, and modulation of glucose and lipid metabolism.
Benefits and Advantages
Used in glucocorticoid‑receptor studies, inflammation‑suppression modelling, HPA‑axis function testing, endocrine pharmacology and metabolic disease research.
Side Effects and Risks
Risks include hyperglycemia, immunosuppression, adrenal feedback inhibition, fluid retention and mood alterations. Handle as a potent systemic glucocorticoid.
Datasheet
| Molecular Formula | C23H30O6 |
|---|---|
| Molecular Weight | 402.5 g/mol |
| CAS Number | 50-04-4 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | CORTISONE ACETATE; Cortisone 21-acetate; 50-04-4; Cortone acetate; Cortisyl |
| IUPAC/Chemical Name | [2-[(8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate |
| InChl Key | ITRJWOMZKQRYTA-RFZYENFJSA-N |
| InChl Code | InChI=1S/C23H30O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-17,20,28H,4-9,11-12H2,1-3H3/t16-,17-,20+,21-,22-,23-/m0/s1 |
| References |
3D Conformer.
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