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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Product Description
Mechanism of Action
ISOCONAZOLE NITRATE (ID 26467) exhibits complex multi‑pathway biochemical interactions involving receptor‑level modulation, regulatory enzyme interference, intracellular signalling adjustment and transcriptomic pathway influence. Its physicochemical profile suggests affinity for catalytic and regulatory protein domains, enabling disruption or enhancement of phosphorylation cycles, redox‑state balance, and mitochondrial performance. In several experimental systems, the compound demonstrates capacity to alter calcium signalling, membrane potential, structural‑protein dynamics and cellular metabolic flux.
Benefits and Advantages
This compound supports high‑resolution biochemical modelling and is suitable for use in:
- Receptor‑ligand binding studies and pathway validation
- Metabolic‑flux assays, mitochondrial‑stress evaluations and ROS‑regulation research
- Multi‑omics profiling (transcriptomics, metabolomics, proteomics)
- Stress‑response signalling, kinase/phosphatase cascade mapping and cytoskeletal dynamics analysis
- Early‑phase pharmacodynamic screening and SAR exploration
Side Effects and Risks
Potential risks include redox imbalance, mitochondrial overload, cytoskeletal disruption, altered membrane integrity, aberrant calcium flux, and dose‑dependent cytotoxicity. At elevated concentrations, the compound may induce apoptosis, autophagy, or transcriptional stress responses. Use only under strict laboratory conditions with appropriate biosafety protocols and controlled exposure.
Datasheet
| Molecular Formula | C18H16Cl3N3O4 |
|---|---|
| Molecular Weight | 479.1 g/mol |
| CAS Number | 24168-96-5 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | isoconazole nitrate; 24168-96-5; 5AS8P3N30X; R 15,454; DTXSID60946995 |
| IUPAC/Chemical Name | 1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]imidazole;nitric acid |
| InChl Key | NNGQLSIGRSTLLU-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C18H14Cl4N2O.HNO3/c19-12-4-5-13(17(22)8-12)18(9-24-7-6-23-11-24)25-10-14-15(20)2-1-3-16(14)21;2-1(3)4/h1-8,11,18H,9-10H2;(H,2,3,4) |
| References |
3D Conformer.
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