KANAMYCIN SULFATE
Kanamycin sulfate is an aminoglycoside antibiotic that inhibits bacterial protein synthesis by binding the 30S ribosomal subunit. It is used for severe gramnegative and some mycobacterial infections. Benefits include potent bactericidal activity. Side effects include nephrotoxicity, irreversible ototoxicity, neuromuscular blockade, and need for serum level monitoring. Only GMP materials will be supplied, logistics all according to GDP.
About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
KANAMYCIN SULFATE exhibits a structured and multilayered biochemical activity profile involving modulation of enzymatic cascades, receptorbinding dynamics, intracellular signalling architecture, and metabolicflux regulation. Its molecular characteristics indicate potential interactions with catalytic pockets, allosteric surfaces, and regulatory protein domains. Through these interactions, the compound influences phosphorylation patterns, mitochondrial bioenergetics, oxidativestress networks, membrane potential stabilization, and transcriptional pathway responsiveness.
In cellular systems, mechanistic effects may include modulation of calcium flux, ROS equilibrium, structuralprotein turnover, and adaptive stressresponse activation. The compound may act as a pathway booster, suppressor, or modulator depending on dosing, cellular environment, and metabolic state.
Benefits and Advantages
This compound is widely used in biochemical, pharmacological and mechanistic research settings, including:
- Receptorligand interaction studies and affinitymapping assays
- Enzyme kinetics and catalyticpathway modelling
- Mitochondrialfunction, ROSregulation and redoxbalance experiments
- Transcriptomic, proteomic and metabolomic profiling
- Cellstress signalling, apoptosis/autophagy pathway mapping and cytoskeletaldynamics studies
- Pharmacodynamic simulation and SAR (structureactivity relationship) analysis
Side Effects and Risks
Risks may include unintended oxidative imbalance, mitochondrial overload, receptor crosstalk effects, disruption of ionchannel homeostasis, and dosedependent cytotoxicity. At elevated concentrations, the compound may trigger apoptosis, autophagy, or compensatory metabolic rewiring. Longterm exposure can influence transcriptional stability, signalling thresholds, and cellular resilience.
Use only in controlled laboratory environments following strict biosafety and handling protocols. Not intended for human or veterinary use.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C18H38N4O15S |
|---|---|
| Molecular Weight | 582.6 g/mol |
| CAS Number | 25389-94-0 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Kanamycin A sulfate; Kanamycin A sulphate; J80EX28SMQ; DTXSID1047524; EINECS 223-347-1 |
| IUPAC/Chemical Name | (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol;sulfuric acid |
| InChl Key | OOYGSFOGFJDDHP-KMCOLRRFSA-N |
| InChl Code | InChI=1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1 |
| References |
3D Conformer.
(Click, turn or enlarge)
Download our GMP API Product List.
MedicaPharma is an EU-based supplier of GMP-certified APIs that serves leading healthcare institutions and research organizations.
Click here to download our full API product list.
