DAPSONE
Darolutamide is a nonsteroidal androgen receptor inhibitor that blocks androgen signaling in prostate cancer cells. It is used for nonmetastatic castrationresistant prostate cancer. Benefits include delayed metastasis and prolonged survival with a relatively favorable CNS sideeffect profile. Adverse effects include fatigue, arthralgia, and mild liver enzyme elevations. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
Dapsone is an antiinflammatory and antimicrobial sulfone that inhibits dihydropteroate synthase in bacteria and suppresses neutrophil myeloperoxidase activity. It reduces reactive oxygen species, modulates inflammatory cytokines and is active against *Mycobacterium leprae* and various inflammatory dermatoses.
Benefits and Advantages
Used in neutrophilfunction studies, MPOinhibition assays, leprosy research, autoimmune blisteringdisease models, and antiinflammatory pathway investigations.
Side Effects and Risks
Risks include hemolysis (especially in G6PD deficiency), methemoglobinemia, neuropathy, rash and hepatotoxicity. Handle with sulfonecompound precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C12H12N2O2S |
|---|---|
| Molecular Weight | 248.30 g/mol |
| CAS Number | 80-08-0 |
| Storage Condition | Keep container tightly closed in a dry and well-ventilated place. Light sensitive. |
| Solubility | less than 1 mg/mL at 68 °F (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | dapsone; 80-08-0; 4,4'-Sulfonyldianiline; Diaphenylsulfone; 4,4'-Diaminodiphenyl sulfone |
| IUPAC/Chemical Name | 4-(4-aminophenyl)sulfonylaniline |
| InChl Key | MQJKPEGWNLWLTK-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2 |
| References |
3D Conformer.
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