About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Clarithromycin is a macrolide antibiotic that binds the 50S ribosomal subunit, inhibiting translocation of peptidyl‑tRNA and halting bacterial protein synthesis. It is acid‑stable and forms an active metabolite (14‑hydroxyclarithromycin) with synergistic activity. Effective against respiratory pathogens, atypicals and gram‑positive organisms.
Benefits and Advantages
Used in ribosome‑binding studies, macrolide‑resistance research (erm methylase pathways), intracellular‑pathogen modelling, PK/PD studies and biofilm‑penetration assays.
Side Effects and Risks
Risks include QT prolongation, hepatotoxicity, GI disturbances, CYP3A4 interactions and risk of arrhythmia. Handle with macrolide‑class precautions.
Datasheet
| Molecular Formula | C38H69NO13 |
|---|---|
| Molecular Weight | 748.0 g/mol |
| CAS Number | 81103-11-9 |
| Storage Condition | Store in tight container as defined in the USP-NF. This material should be handled and stored per label instructions to ensure product integrity. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | clarithromycin; 81103-11-9; Biaxin; 6-O-Methylerythromycin; Klaricid |
| IUPAC/Chemical Name | (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione |
| InChl Key | AGOYDEPGAOXOCK-KCBOHYOISA-N |
| InChl Code | InChI=1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1 |
| References |
3D Conformer.
(Click, turn or enlarge)
Download our GMP API Product List.
MedicaPharma is an EU-based supplier of GMP-certified APIs that serves leading healthcare institutions and research organizations.
Click here to download our full API product list.
