About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Ceftazidime pentahydrate is a hydrated form of ceftazidime, a thirdgeneration cephalosporin with potent activity against gramnegative organisms, especially *Pseudomonas aeruginosa*. It binds PBPs and disrupts cellwall crosslinking. The pentahydrate form provides stability advantages for storage and formulation.
Benefits and Advantages
Used in pseudomonalresistance modelling, lactamasemechanism studies, ICU pathogen susceptibility profiling, pharmacokinetic simulations and comparative antipseudomonal research. Also valuable in biofilm and nosocomial infection models.
Side Effects and Risks
Risks include neurotoxicity in renal impairment, hypersensitivity, GI effects and emergence of resistant subpopulations. Handle as a highpotency lactam.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C22H22N6O7S2·5H2O |
|---|---|
| Molecular Weight | 636.7 g/mol |
| CAS Number | 78439-06-2 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Ceftazidime pentahydrate; Ceftazidime hydrate; 78439-06-2; DTXSID0045599; CHEBI:3509 |
| IUPAC/Chemical Name | (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2-carboxypropan-2-yloxyimino)acetyl]amino]-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;pentahydrate |
| InChl Key | NMVPEQXCMGEDNH-TZVUEUGBSA-N |
| InChl Code | InChI=1S/C22H22N6O7S2.5H2O/c1-22(2,20(33)34)35-26-13(12-10-37-21(23)24-12)16(29)25-14-17(30)28-15(19(31)32)11(9-36-18(14)28)8-27-6-4-3-5-7-27;;;;;/h3-7,10,14,18H,8-9H2,1-2H3,(H4-,23,24,25,29,31,32,33,34);5*1H2/b26-13-;;;;;/t14-,18-;;;;;/m1…../s1 |
| References |
3D Conformer.
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