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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Product Description
Mechanism of Action
Cefaloridine is a first-generation cephalosporin with strong PBP-binding affinity but notable nephrotoxicity due to transport-mediated accumulation in renal proximal tubules. It disrupts peptidoglycan crosslinking and exhibits strong gram-positive activity with moderate gram-negative coverage.
Benefits and Advantages
Used in renal-toxicity modelling, mitochondrial oxidative-injury studies, cephalosporin SAR research, bacterial cell-wall mechanism studies, and nephrotoxicity-protection assays.
Side Effects and Risks
Risks include nephrotoxicity (dose-limiting), hypersensitivity, electrolyte imbalance and tubular injury. Handle with strict renal-toxicity precautions.
Datasheet
| Molecular Formula | C19H17N3O4S2 |
|---|---|
| Molecular Weight | 415.5 g/mol |
| CAS Number | 50-59-9 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | SOL IN WATER |
| Purity | Purity information is available upon request (COA). |
| Synonym | cephaloridine; cefaloridine; 50-59-9; Cephaloridin; Cephaloridinum |
| IUPAC/Chemical Name | (6R,7R)-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
| InChl Key | CZTQZXZIADLWOZ-CRAIPNDOSA-N |
| InChl Code | InChI=1S/C19H17N3O4S2/c23-14(9-13-5-4-8-27-13)20-15-17(24)22-16(19(25)26)12(11-28-18(15)22)10-21-6-2-1-3-7-21/h1-8,15,18H,9-11H2,(H-,20,23,25,26)/t15-,18-/m1/s1 |
| References |
3D Conformer.
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