PARBENDAZOLE
Parbendazole is a benzimidazole anthelmintic that binds to tubulin in parasites, inhibiting microtubule assembly and disrupting glucose uptake, ultimately killing the worms. It is used in veterinary and experimental settings. Side effects may include mild gastrointestinal upset, diarrhea, transient liver enzyme elevation, and rare hypersensitivity reactions with repeated or highdose exposure. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
PARBENDAZOLE exhibits a multidimensional biochemical activity profile involving modulation of enzyme-catalyzed pathways, receptor-mediated intracellular signaling, ion-channel regulation, mitochondrial bioenergetics, oxidative-stress balancing, membrane dynamics, and transcription-factor orchestration. Its molecular configuration allows high-affinity interaction with catalytic residues, allosteric domains, regulatory scaffolds, and signaling intermediates, influencing phosphorylation cycles, secondmessenger flux (Ca²⁺, cAMP, IP, DAG), ROS equilibrium, ATP synthesis, and mitochondrial respiratory-chain regulation.
Depending on dose, exposure duration, and cell type, PARBENDAZOLE can modify chromatin accessibility, metabolic flux routing, vesicular trafficking, cytoskeletal structure, and gene-expression clusters associated with survival, inflammation, apoptosis, autophagy, and metabolic adaptation.
Benefits and Advantages
Due to its consistent mechanistic behavior, this compound is utilized in advanced research, including:
- Receptorligand interaction studies and affinity modeling
- Highresolution enzyme kinetics and catalytic-pathway deconstruction
- Mitochondrial ATPflux assays and oxidativestress system modeling
- Multiomics profiling (transcriptomics, proteomics, metabolomics, phosphoproteomics)
- Cytoskeletal and membranedynamics exploration
- Apoptosis, ferroptosis, necroptosis, and autophagy pathway analysis
- Structureactivity relationship (SAR) investigations and compound optimization
- Pharmacodynamic modeling, mechanistic doseresponse scaling, and pathway benchmarking
Side Effects and Risks
Potential laboratory risks include:
- Oxidativestress imbalance and ROS accumulation
- Mitochondrial overload or respiratory-chain suppression
- Ionchannel dysregulation affecting Ca²⁺/Na⁺/K⁺ homeostasis
- Unintended receptor crossactivation or pathway inhibition
- Cytoskeletal destabilization and membrane-integrity disruption
- Dose-dependent cytotoxicity (apoptotic or autophagic induction)
- Transcriptional or epigenetic instability under prolonged exposure
- Activation of inflammatory signaling networks (NF-κB, JNK, p38 MAPK)
Use strictly in controlled laboratory environments with appropriate biosafety protocols.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C12H15N3O3S |
|---|---|
| Molecular Weight | 247.29 g/mol |
| CAS Number | 14255-87-9 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | less than 1 mg/mL at 64 °F (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | Parbendazole; 14255-87-9; Verminum; Worm Guard; Parbendazol |
| IUPAC/Chemical Name | methyl N-(6-butyl-1H-benzimidazol-2-yl)carbamate |
| InChl Key | YRWLZFXJFBZBEY-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C13H17N3O2/c1-3-4-5-9-6-7-10-11(8-9)15-12(14-10)16-13(17)18-2/h6-8H,3-5H2,1-2H3,(H2,14,15,16,17) |
| References |
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