PARAXETINE HCL
Paroxetine HCl is a selective serotonin reuptake inhibitor (SSRI) that increases synaptic serotonin levels, used to treat depression, anxiety disorders, OCD, and PTSD. Benefits include mood stabilization and reduction of anxiety and intrusive thoughts. Side effects include nausea, sexual dysfunction, weight changes, insomnia or somnolence, sweating, and discontinuation syndrome if stopped abruptly, as well as rare hyponatremia or serotonin syndrome.
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Product Description
Mechanism of Action
PARAXETINE HCL (ID 27021) exhibits a multidimensional biochemical activity profile involving modulation of enzyme-catalyzed pathways, receptor-mediated intracellular signaling, ion-channel regulation, mitochondrial bioenergetics, oxidative-stress balancing, membrane dynamics, and transcription-factor orchestration. Its molecular configuration allows high-affinity interaction with catalytic residues, allosteric domains, regulatory scaffolds, and signaling intermediates, influencing phosphorylation cycles, second‑messenger flux (Ca²⁺, cAMP, IP₃, DAG), ROS equilibrium, ATP synthesis, and mitochondrial respiratory-chain regulation.
Depending on dose, exposure duration, and cell type, PARAXETINE HCL can modify chromatin accessibility, metabolic flux routing, vesicular trafficking, cytoskeletal structure, and gene-expression clusters associated with survival, inflammation, apoptosis, autophagy, and metabolic adaptation.
Benefits and Advantages
Due to its consistent mechanistic behavior, this compound is utilized in advanced research, including:
- Receptor–ligand interaction studies and affinity modeling
- High‑resolution enzyme kinetics and catalytic-pathway deconstruction
- Mitochondrial ATP‑flux assays and oxidative‑stress system modeling
- Multi‑omics profiling (transcriptomics, proteomics, metabolomics, phosphoproteomics)
- Cytoskeletal and membrane‑dynamics exploration
- Apoptosis, ferroptosis, necroptosis, and autophagy pathway analysis
- Structure–activity relationship (SAR) investigations and compound optimization
- Pharmacodynamic modeling, mechanistic dose–response scaling, and pathway benchmarking
Side Effects and Risks
Potential laboratory risks include:
- Oxidative‑stress imbalance and ROS accumulation
- Mitochondrial overload or respiratory-chain suppression
- Ion‑channel dysregulation affecting Ca²⁺/Na⁺/K⁺ homeostasis
- Unintended receptor cross‑activation or pathway inhibition
- Cytoskeletal destabilization and membrane‑integrity disruption
- Dose-dependent cytotoxicity (apoptotic or autophagic induction)
- Transcriptional or epigenetic instability under prolonged exposure
- Activation of inflammatory signaling networks (NF‑κB, JNK, p38 MAPK)
Use strictly in controlled laboratory environments with appropriate biosafety protocols.
Datasheet
| Molecular Formula | C19H20FNO3·HCl |
|---|---|
| Molecular Weight | 365.24 g/mol |
| CAS Number | 61869-08-7 |
| Storage Condition | Store at 2-8°C |
| Solubility | Soluble in water |
| Purity | Purity information is available upon request (COA). |
| Synonym | 3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine; 3-[(2H-1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine; 72473-26-8; 3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine; Paxetil |
| IUPAC/Chemical Name | (3S,4R)-3-(dimethylamino)-1-phenylpropan-1-ol hydrochloride |
| InChl Key | Unavailable |
| InChl Code | Unavailable |
| References | PubChem; ChemBL; FDA; |
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