ISOXICAM
Isoxicam is an oxicam‑class NSAID that inhibits cyclooxygenase enzymes, reducing prostaglandin synthesis and thereby inflammation, pain, and fever. It is used in rheumatic and musculoskeletal conditions. Benefits include long‑lasting analgesia. Side effects may include gastrointestinal irritation, ulceration, dizziness, hypersensitivity reactions, and potential renal or hepatic effects with prolonged use.
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Product Description
Mechanism of Action
ISOXICAM (ID 26480) exhibits complex multi‑pathway biochemical interactions involving receptor‑level modulation, regulatory enzyme interference, intracellular signalling adjustment and transcriptomic pathway influence. Its physicochemical profile suggests affinity for catalytic and regulatory protein domains, enabling disruption or enhancement of phosphorylation cycles, redox‑state balance, and mitochondrial performance. In several experimental systems, the compound demonstrates capacity to alter calcium signalling, membrane potential, structural‑protein dynamics and cellular metabolic flux.
Benefits and Advantages
This compound supports high‑resolution biochemical modelling and is suitable for use in:
- Receptor‑ligand binding studies and pathway validation
- Metabolic‑flux assays, mitochondrial‑stress evaluations and ROS‑regulation research
- Multi‑omics profiling (transcriptomics, metabolomics, proteomics)
- Stress‑response signalling, kinase/phosphatase cascade mapping and cytoskeletal dynamics analysis
- Early‑phase pharmacodynamic screening and SAR exploration
Side Effects and Risks
Potential risks include redox imbalance, mitochondrial overload, cytoskeletal disruption, altered membrane integrity, aberrant calcium flux, and dose‑dependent cytotoxicity. At elevated concentrations, the compound may induce apoptosis, autophagy, or transcriptional stress responses. Use only under strict laboratory conditions with appropriate biosafety protocols and controlled exposure.
Datasheet
| Molecular Formula | C14H13N3O4S |
|---|---|
| Molecular Weight | 335.34 g/mol |
| CAS Number | 34552-84-6 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | 33.9 [ug/mL] (The mean of the results at pH 7.4) |
| Purity | Purity information is available upon request (COA). |
| Synonym | isoxicam; 34552-84-6; Maxicam; Isoxicamum; Isoxicamo |
| IUPAC/Chemical Name | 4-hydroxy-2-methyl-N-(5-methyl-1,2-oxazol-3-yl)-1,1-dioxo-1lambda6,2-benzothiazine-3-carboxamide |
| InChl Key | YYUAYBYLJSNDCX-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C14H13N3O5S/c1-8-7-11(16-22-8)15-14(19)12-13(18)9-5-3-4-6-10(9)23(20,21)17(12)2/h3-7,18H,1-2H3,(H,15,16,19) |
| References |
3D Conformer.
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