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Product Description
Mechanism of Action
Etofibrate is a prodrug conjugate of clofibrate and theophylline. After enzymatic hydrolysis, it releases clofibric acid (a PPAR‑α activator that enhances lipid metabolism) and theophylline (a xanthine bronchodilator). This dual‑action profile influences lipid homeostasis and respiratory smooth‑muscle function.
Benefits and Advantages
Used in lipid‑metabolism modelling, PPAR‑α activation assays, dual‑prodrug studies, and xanthine‑bronchodilator pharmacology.
Side Effects and Risks
Risks include GI discomfort, hepatotoxicity, tachycardia (from theophylline), and photosensitivity. Handle with fibrate‑xanthine combination precautions.
Datasheet
| Molecular Formula | C20H26O6 |
|---|---|
| Molecular Weight | 363.8 g/mol |
| CAS Number | 31637-97-5 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Etofibrate; 31637-97-5; Etofibrato; Etofibratum; DTXSID80185521 |
| IUPAC/Chemical Name | 2-[2-(4-chlorophenoxy)-2-methylpropanoyl]oxyethyl pyridine-3-carboxylate |
| InChl Key | XXRVYAFBUDSLJX-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C18H18ClNO5/c1-18(2,25-15-7-5-14(19)6-8-15)17(22)24-11-10-23-16(21)13-4-3-9-20-12-13/h3-9,12H,10-11H2,1-2H3 |
| References |
3D Conformer.
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