About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Entacapone is a selective, reversible inhibitor of catechol‑O‑methyltransferase (COMT). COMT normally metabolizes levodopa and dopamine via methylation, reducing their bioavailability. By inhibiting peripheral COMT, entacapone prolongs levodopa plasma half‑life, stabilizes dopaminergic stimulation and smooths motor fluctuations in Parkinsonian models. It does not cross the blood–brain barrier significantly.
Benefits and Advantages
Used in dopaminergic‑pathway research, COMT‑inhibition assays, Parkinson’s disease pharmacokinetic modelling, and levodopa‑synergy studies.
Side Effects and Risks
Risks include diarrhea, orange urine discoloration, dyskinesia (via enhanced levodopa effect), hepatotoxicity (rare), and orthostatic hypotension. Handle with COMT‑inhibitor precautions.
Datasheet
| Molecular Formula | C14H15NO5 |
|---|---|
| Molecular Weight | 305.29 g/mol |
| CAS Number | 130929-57-6 |
| Storage Condition | Store at 25 °C (77 °F); excursions permitted to 15 °C to 30 °C (59 °F to 86 °F). |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | ENTACAPONE; 130929-57-6; Comtan; Comtess; Entacapona |
| IUPAC/Chemical Name | (E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide |
| InChl Key | JRURYQJSLYLRLN-BJMVGYQFSA-N |
| InChl Code | InChI=1S/C14H15N3O5/c1-3-16(4-2)14(20)10(8-15)5-9-6-11(17(21)22)13(19)12(18)7-9/h5-7,18-19H,3-4H2,1-2H3/b10-5+ |
| References |
3D Conformer.
(Click, turn or enlarge)
Download our GMP API Product List.
MedicaPharma is an EU-based supplier of GMP-certified APIs that serves leading healthcare institutions and research organizations.
Click here to download our full API product list.
