About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Entecavir is a potent guanosine nucleoside analogue with high affinity for HBV DNA polymerase. It inhibits priming, reverse transcription of pregenomic RNA and synthesis of the positive DNA strand. It incorporates into viral DNA, causing chain termination. Exhibits strong activity against wildtype and lamivudineresistant HBV.
Benefits and Advantages
Used in HBV replicationpathway research, reversetranscriptase inhibition assays, nucleosideanalogue SAR studies, and viralDNA polymerization modelling.
Side Effects and Risks
Risks include lactic acidosis, hepatomegaly with steatosis, headache, fatigue and rebound hepatitis upon withdrawal. Handle with antiviralnucleoside precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C12H15N5O3·H2O |
|---|---|
| Molecular Weight | 295.29 g/mol |
| CAS Number | 209216-23-9 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Entecavir hydrate; entecavir monohydrate; 209216-23-9; Entecavir hydrate (JAN); Entecavir (USP) |
| IUPAC/Chemical Name | 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1H-purin-6-one;hydrate |
| InChl Key | YXPVEXCTPGULBZ-WQYNNSOESA-N |
| InChl Code | InChI=1S/C12H15N5O3.H2O/c1-5-6(3-18)8(19)2-7(5)17-4-14-9-10(17)15-12(13)16-11(9)20;/h4,6-8,18-19H,1-3H2,(H3,13,15,16,20);1H2/t6-,7-,8-;/m0./s1 |
| References |
3D Conformer.
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