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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Product Description
Mechanism of Action
Eflornithine hydrochloride is an irreversible inhibitor of ornithine decarboxylase (ODC), the rate‑limiting enzyme in polyamine synthesis. By blocking putrescine and spermidine production, it disrupts cell proliferation. It is also active against trypanosomes due to their dependence on polyamine pathways.
Benefits and Advantages
Used in polyamine‑biosynthesis research, cell‑cycle studies, antiproliferative mechanism assays, and parasitology modelling (Trypanosoma spp.).
Side Effects and Risks
Risks include anemia, leukopenia, diarrhea, hearing loss and seizures at very high exposures. Handle with antiproliferative‑agent precautions.
Datasheet
| Molecular Formula | C6H15ClF2N2O3 |
|---|---|
| Molecular Weight | 236.64 g/mol |
| CAS Number | 96020-91-6 |
| Storage Condition | Store at 25 °C (77 °F); excursions permitted to 15 °C – 30 °C (59 °F – 86 °F) |
| Solubility | >10 mg/mL |
| Purity | Purity information is available upon request (COA). |
| Synonym | 96020-91-6; Eflornithine hydrochloride monohydrate; Eflornithine HCl; Iwilfin; MDL 71,782 A |
| IUPAC/Chemical Name | 2,5-diamino-2-(difluoromethyl)pentanoic acid;hydrate;hydrochloride |
| InChl Key | FJPAMFNRCFEGSD-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C6H12F2N2O2.ClH.H2O/c7-4(8)6(10,5(11)12)2-1-3-9;;/h4H,1-3,9-10H2,(H,11,12);1H;1H2 |
| References |
3D Conformer.
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