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Product Description
Mechanism of Action
Dutasteride is a dual 5‑α‑reductase inhibitor (types 1 and 2), blocking conversion of testosterone to dihydrotestosterone (DHT). This reduces androgenic signalling in prostate tissue, hair follicles and sebaceous glands. It lowers DHT levels more profoundly than finasteride.
Benefits and Advantages
Used in androgen‑pathway studies, prostate‑biology modelling, hair‑follicle miniaturization research, and endocrine‑axis inhibition assays.
Side Effects and Risks
Risks include decreased libido, gynecomastia, erectile changes and potential reproductive effects. Handle with potent androgen‑modulator precautions.
Datasheet
| Molecular Formula | C27H30F6N2O2 |
|---|---|
| Molecular Weight | 528.5 g/mol |
| CAS Number | 164656-23-9 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Insoluble |
| Purity | Purity information is available upon request (COA). |
| Synonym | Dutasteride; 164656-23-9; Avodart; Avolve; GG-745 |
| IUPAC/Chemical Name | (1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-[2,5-bis(trifluoromethyl)phenyl]-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide |
| InChl Key | JWJOTENAMICLJG-QWBYCMEYSA-N |
| InChl Code | InChI=1S/C27H30F6N2O2/c1-24-11-9-17-15(4-8-21-25(17,2)12-10-22(36)35-21)16(24)6-7-19(24)23(37)34-20-13-14(26(28,29)30)3-5-18(20)27(31,32)33/h3,5,10,12-13,15-17,19,21H,4,6-9,11H2,1-2H3,(H,34,37)(H,35,36)/t15-,16-,17-,19+,21+,24-,25+/m0/s1 |
| References |
3D Conformer.
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