About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Dupilumab is a fully human monoclonal antibody that blocks the IL4R subunit, inhibiting both IL4 and IL13 signalling. These cytokines drive type2 inflammation, epithelial barrier dysfunction and IgE class switching. Dupilumab disrupts STAT6mediated transcription and reduces eosinophilic inflammation.
Benefits and Advantages
Used in type2 immunity research, atopicdermatitis modelling, IL4/IL13 pathway studies, biologicmechanism analysis and epithelialinflammation assays.
Side Effects and Risks
Risks include conjunctivitis, injectionsite reactions, eosinophilia, herpes viral infections and rare hypersensitivity. Handle with monoclonalantibody precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C6500H10176N1720O2024S42 |
|---|---|
| Molecular Weight | 147000.0 g/mol |
| CAS Number | 1190268-29-6 |
| Storage Condition | Store in a cool, dry place; protect from light |
| Solubility | Soluble in water |
| Purity | Purity information is available upon request (COA). |
| IUPAC/Chemical Name | Human monoclonal IgG4 antibody |
| InChl Key | Unavailable |
| InChl Code | Unavailable |
| References | PubChem; ChemBL; FDA; |
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