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Product Description
Mechanism of Action
Doxacurium chloride is a long‑acting, non‑depolarizing neuromuscular‑blocking agent belonging to the benzylisoquinolinium class. It competitively inhibits nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction, preventing acetylcholine binding and blocking depolarization. The result is flaccid skeletal‑muscle paralysis. Its high potency and long duration make it useful in mechanistic studies of neuromuscular transmission.
Benefits and Advantages
Used in neuromuscular‑junction physiology studies, nAChR‑binding assays, skeletal‑muscle blockade modelling, acetylcholine‑competition experiments, and pharmacodynamic characterisation of non‑depolarizing muscle relaxants.
Side Effects and Risks
Risks include prolonged paralysis, respiratory depression, histamine release, hypotension, bronchospasm and cumulative neuromuscular blockade. Handle with high‑potency paralytic‑agent precautions.
Datasheet
| Molecular Formula | C56H78Cl2N2O16 |
|---|---|
| Molecular Weight | 1106.1 g/mol |
| CAS Number | 106819-53-8 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | DOXACURIUM CHLORIDE; Doxacurii chloridum; Cloruro de doxacurio; Chlorure de doxacurium; 106819-53-8 |
| IUPAC/Chemical Name | 1-O-[3-[(1S,2R)-6,7,8-trimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propyl] 4-O-[3-[(1R,2S)-6,7,8-trimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propyl] butanedioate dichloride |
| InChl Key | APADFLLAXHIMFU-LGIHQUBZSA-L |
| InChl Code | InChI=1S/C56H78N2O16.2ClH/c1-57(23-19-37-33-45(65-7)53(69-11)55(71-13)49(37)39(57)27-35-29-41(61-3)51(67-9)42(30-35)62-4)21-15-25-73-47(59)17-18-48(60)74-26-16-22-58(2)24-20-38-34-46(66-8)54(70-12)56(72-14)50(38)40(58)28-36-31-43(63-5)52(68-10)44(32-36)64-6;;/h29-34,39-40H,15-28H2,1-14H3;2*1H/q+2;;/p-2/t39-,40+,57-,58+;; |
| References |
3D Conformer.
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