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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
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Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Doxacurium chloride is a longacting, nondepolarizing neuromuscularblocking agent belonging to the benzylisoquinolinium class. It competitively inhibits nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction, preventing acetylcholine binding and blocking depolarization. The result is flaccid skeletalmuscle paralysis. Its high potency and long duration make it useful in mechanistic studies of neuromuscular transmission.
Benefits and Advantages
Used in neuromuscularjunction physiology studies, nAChRbinding assays, skeletalmuscle blockade modelling, acetylcholinecompetition experiments, and pharmacodynamic characterisation of nondepolarizing muscle relaxants.
Side Effects and Risks
Risks include prolonged paralysis, respiratory depression, histamine release, hypotension, bronchospasm and cumulative neuromuscular blockade. Handle with highpotency paralyticagent precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C56H78Cl2N2O16 |
|---|---|
| Molecular Weight | 1106.1 g/mol |
| CAS Number | 106819-53-8 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | DOXACURIUM CHLORIDE; Doxacurii chloridum; Cloruro de doxacurio; Chlorure de doxacurium; 106819-53-8 |
| IUPAC/Chemical Name | 1-O-[3-[(1S,2R)-6,7,8-trimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propyl] 4-O-[3-[(1R,2S)-6,7,8-trimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propyl] butanedioate dichloride |
| InChl Key | APADFLLAXHIMFU-LGIHQUBZSA-L |
| InChl Code | InChI=1S/C56H78N2O16.2ClH/c1-57(23-19-37-33-45(65-7)53(69-11)55(71-13)49(37)39(57)27-35-29-41(61-3)51(67-9)42(30-35)62-4)21-15-25-73-47(59)17-18-48(60)74-26-16-22-58(2)24-20-38-34-46(66-8)54(70-12)56(72-14)50(38)40(58)28-36-31-43(63-5)52(68-10)44(32-36)64-6;;/h29-34,39-40H,15-28H2,1-14H3;2*1H/q+2;;/p-2/t39-,40+,57-,58+;; |
| References |
3D Conformer.
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