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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Domperidone is a peripherally selective dopamine D/D receptor antagonist that enhances gastrointestinal motility and increases loweresophageal sphincter tone by blocking dopaminemediated inhibition of acetylcholine release. It also raises prolactin levels via pituitary D blockade but minimally crosses the bloodbrain barrier.
Benefits and Advantages
Used in GI motility research, Dpathway signalling studies, prokinetic mechanism assays, and endocrineprolactin axis investigations.
Side Effects and Risks
Risks include QT prolongation, ventricular arrhythmias, hyperprolactinemia, gynecomastia and GI cramps. Handle with dopamineantagonist precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C22H24ClN5O2 |
|---|---|
| Molecular Weight | 425.9 g/mol |
| CAS Number | 57808-66-9 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | domperidone; 57808-66-9; Motilium; Domperidona; Domperidonum |
| IUPAC/Chemical Name | 6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one |
| InChl Key | FGXWKSZFVQUSTL-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30) |
| References |
3D Conformer.
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