About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Dimethyl fumarate (DMF) is an immunomodulatory compound that activates the Nrf2 antioxidant pathway and reduces NF-κB signalling. Its electrophilic properties allow covalent modification of KEAP1 cysteines, releasing Nrf2 and promoting transcription of detoxifying and cytoprotective genes. It also shifts Tcell populations toward antiinflammatory phenotypes.
Benefits and Advantages
Used in oxidativestress modelling, Nrf2pathway studies, immunemodulation research, electrophilicdrug mechanism assays and neuroinflammation studies.
Side Effects and Risks
Risks include lymphopenia, flushing, GI irritation, hepatotoxicity, PML risk (very rare) and cutaneous reactions. Handle with electrophilicimmunomodulator precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C6H8O4 |
|---|---|
| Molecular Weight | 144.12 g/mol |
| CAS Number | 624-49-7 |
| Storage Condition | Store at 15 °C to 30 °C (59 to 86 °F). Protect the capsules from light. Store in original container. |
| Solubility | Highly soluble in water |
| Purity | Purity information is available upon request (COA). |
| Synonym | Dimethyl fumarate; 624-49-7; Tecfidera; Fumaric acid dimethyl ester; Dimethylfumarate |
| IUPAC/Chemical Name | dimethyl (E)-but-2-enedioate |
| InChl Key | LDCRTTXIJACKKU-ONEGZZNKSA-N |
| InChl Code | InChI=1S/C6H8O4/c1-9-5(7)3-4-6(8)10-2/h3-4H,1-2H3/b4-3+ |
| References |
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