DIAZOXID
Diazoxide is a potassium channel opener that relaxes vascular smooth muscle and inhibits insulin release. It is used for hypertensive emergencies and hypoglycemia due to excessive insulin secretion. Side effects include fluid retention, hyperglycemia, tachycardia, and hypotension. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
Diazoxide is a potassiumchannel opener that activates ATPsensitive K⁺ channels (K_ATP) in pancreatic cells, vascular smooth muscle and cardiac tissue. In cells it inhibits insulin release by hyperpolarizing the membrane. In smooth muscle, it produces vasodilation through decreased calcium influx.
Benefits and Advantages
Used in K_ATPchannel research, insulinsecretion modelling, vasculardilation studies, metabolicsyndrome research, and cardiacelectrophysiology assays.
Side Effects and Risks
Risks include hyperglycemia, edema, hypotension, tachycardia, hirsutism and electrolyte disturbances. Handle with ionchannel modulator precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C8H7ClN2O2S |
|---|---|
| Molecular Weight | 230.67 g/mol |
| CAS Number | 364-98-7 |
| Storage Condition | Store in a cool, dry place; protect from light |
| Solubility | Soluble in water |
| Purity | Purity information is available upon request (COA). |
| Synonym | diazoxide; 364-98-7; Proglycem; Hyperstat; Hypertonalum |
| IUPAC/Chemical Name | 7-chloro-3-methyl-2H-1,2,4-benzothiadiazin-1,1-dioxide |
| InChl Key | Unavailable |
| InChl Code | Unavailable |
| References | PubChem; ChemBL; FDA; |
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