DEBRISOQUINE
Daunorubicin is an anthracycline antineoplastic agent that intercalates DNA and inhibits topoisomerase II, leading to strand breaks and apoptosis. It is used in acute leukemias. Benefits include strong cytotoxicity and established combination regimens. Side effects include cardiotoxicity, myelosuppression, mucositis, and alopecia.
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Product Description
Mechanism of Action
Debrisoquine is a substrate of cytochrome P450 2D6 (CYP2D6) and is used extensively as a probe to phenotype oxidative metabolism. Its mechanism involves adrenergic neuron blockade and partial inhibition of norepinephrine reuptake, though its primary scientific use is in metabolic enzyme profiling.
Benefits and Advantages
Used in CYP2D6 phenotyping studies, pharmacogenomics research, drug‑metabolism modelling, adrenergic‑pathway analysis, and personalised‑medicine investigations.
Side Effects and Risks
Risks include hypotension, dizziness, syncope, urinary retention and hypersensitivity reactions. Handle with adrenergic‑modulator precautions.
Datasheet
| Molecular Formula | C10H13N3 |
|---|---|
| Molecular Weight | 175.23 g/mol |
| CAS Number | 1131-64-2 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Debrisoquine; Debrisoquin; 1131-64-2; Debrisochinum; Debrisoquina |
| IUPAC/Chemical Name | 3,4-dihydro-1H-isoquinoline-2-carboximidamide |
| InChl Key | JWPGJSVJDAJRLW-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C10H13N3/c11-10(12)13-6-5-8-3-1-2-4-9(8)7-13/h1-4H,5-7H2,(H3,11,12) |
| References |
3D Conformer.
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