DAPAGLIFLOZIN
Dapagliflozin is an SGLT2 inhibitor that lowers blood glucose by promoting urinary glucose excretion. It is used in type 2 diabetes, heart failure, and chronic kidney disease. Benefits include improved glycemic control, weight reduction, and cardioprotective and renoprotective effects. Side effects include genital infections, volume depletion, and rare ketoacidosis. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
Dapagliflozin is a sodiumglucose cotransporter2 (SGLT2) inhibitor that blocks glucose reabsorption in the proximal renal tubule, promoting glycosuria and lowering plasma glucose independently of insulin. It also reduces intraglomerular pressure, improves cardiorenal outcomes and modulates metabolic biomarkers.
Benefits and Advantages
Used in renalglucose transport research, metabolismpathway modelling, cardiorenalprotection studies, SGLT2binding assays and diabetesmechanism investigations.
Side Effects and Risks
Risks include euglycemic ketoacidosis, urinary infections, dehydration, hypotension and electrolyte imbalances. Handle with antidiabeticagent precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C21H25ClO6 |
|---|---|
| Molecular Weight | 408.9 g/mol |
| CAS Number | 461432-26-8 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Dapagliflozin; 461432-26-8; BMS-512148; Forxiga; BMS 512148 |
| IUPAC/Chemical Name | (2S,3R,4R,5S,6R)-2-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol |
| InChl Key | JVHXJTBJCFBINQ-ADAARDCZSA-N |
| InChl Code | InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1 |
| References |
3D Conformer.
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