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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Clozapine is an atypical antipsychotic with high affinity for D dopaminergic receptors and potent antagonism at 5HTA receptors. It also modulates histamine, muscarinic and adrenergic receptors. Clozapine reduces mesolimbic dopaminergic signalling while sparing nigrostriatal pathways, giving it strong antipsychotic effects with minimal extrapyramidal symptoms. It additionally enhances NMDAglutamatergic function through indirect modulation.
Benefits and Advantages
Used in schizophreniamodel research, dopaminergic/serotonergicpathway analysis, neuroinflammation studies, treatmentresistant psychosis modelling, and complex receptorbinding investigations.
Side Effects and Risks
Risks include agranulocytosis, myocarditis, seizures, metabolic syndrome, tachycardia, sedation and hypersalivation. Handle with strict CNSactive and hematologicrisk controls.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C18H19ClN4 |
|---|---|
| Molecular Weight | 326.8 g/mol |
| CAS Number | 5786-21-0 |
| Storage Condition | Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | clozapine; 5786-21-0; Leponex; Clozapin; CLOZARIL |
| IUPAC/Chemical Name | 3-chloro-6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine |
| InChl Key | QZUDBNBUXVUHMW-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3 |
| References |
3D Conformer.
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