About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Cebranopadol is a first-in-class analgesic acting as a mixed nociceptin/orphanin FQ peptide receptor (NOP) agonist and μ-opioid receptor (MOR) agonist. It activates Gi/o protein–coupled pathways, inhibiting adenylate cyclase, reducing neuronal excitability, and suppressing pain transmission. The dual NOP/MOR mechanism enhances analgesia while reducing classic opioid side effects such as respiratory depression and high abuse liability.
Benefits and Advantages
Used in pain-modulation research, NOP-receptor pharmacology, neuropathic-pain modelling, opioid-receptor signalling studies, analgesic-pathway comparisons, and behavioural addiction research. Offers unique mechanistic value for next-generation analgesics.
Side Effects and Risks
Risks include dizziness, nausea, mild respiratory effects, CNS depression and potential dependence at high doses. Handle under CNS-active opioid-agonist precautions.
Datasheet
| Molecular Formula | C24H27FN2O |
|---|---|
| Molecular Weight | 378.5 g/mol |
| CAS Number | 863513-91-1 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Cebranopadol; 863513-91-1; GRT6005; 863513-93-3; Cebranopadol ((1alpha,4alpha)stereoisomer) |
| IUPAC/Chemical Name | 6-fluoro-N,N-dimethyl-1'-phenylspiro[4,9-dihydro-3H-pyrano[3,4-b]indole-1,4'-cyclohexane]-1'-amine |
| InChl Key | CSMVOZKEWSOFER-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C24H27FN2O/c1-27(2)23(17-6-4-3-5-7-17)11-13-24(14-12-23)22-19(10-15-28-24)20-16-18(25)8-9-21(20)26-22/h3-9,16,26H,10-15H2,1-2H3 |
| References |
3D Conformer.
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