About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
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Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of action
Carbamazepine is an anticonvulsant and mood stabiliser that blocks voltage‑gated sodium channels in neurons, stabilising inactive states and reducing high‑frequency neuronal firing. It also modulates glutamate release and affects adrenergic, serotonergic and dopaminergic systems. Its membrane‑stabilising effects reduce seizures and neuropathic pain signalling.
Benefits and advantages
Used in epilepsy research, neuropathic‑pain models, sodium‑channel electrophysiology studies, mood‑stabilisation mechanism research and drug‑interaction/PK pathway analysis.
Side effects and risks
Risks include hepatotoxicity, hyponatraemia, dizziness, agranulocytosis, dermatologic hypersensitivity (SJS/TEN) and CNS depression. Handle with anticonvulsant‑active compound controls.
Datasheet
| Molecular Formula | C15H12N2O |
|---|---|
| Molecular Weight | 236.27 g/mol |
| CAS Number | 65208-33-1 |
| Storage Condition | Carbamazepine tablets, extended-release tablets, and chewable tablets should be stored in tight, light-resistant containers at temperatures not exceeding 30 °C. Carbamazepine extended-release capsules should be stored in tight, light-resistant containers at 15-25 °C. Because dissolution characteristics and associated oral bioavailability of carbamazepine tablets may be affected substantially by moisture, patients should be cautioned to keep containers of the tablets tightly closed and in a dry location, away from areas with excessive moisture (e.g., showers, bathrooms, humidifiers). Carbamazepine tablets may lose one-third or more of their oral bioavailability when exposed to excessive moisture. Tablets continuously exposed to 97% relative humidity at room temperature for 2 weeks become hardened and dissolve poorly. |
| Solubility | Sol in alcohol, acetone, propylene glycol; practically insol in water |
| Purity | Purity information is available upon request (COA). |
| Synonym | carbamazepine; 298-46-4; Tegretol; Carbamazepen; Finlepsin |
| IUPAC/Chemical Name | benzo[b][1]benzazepine-11-carboxamide |
| InChl Key | FFGPTBGBLSHEPO-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C15H12N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-10H,(H2,16,18) |
| References |
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