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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Product Description
Mechanism of action
Budesonide is a potent glucocorticoid with high topical anti‑inflammatory activity and strong glucocorticoid‑receptor affinity. After cellular uptake, it suppresses transcription of pro‑inflammatory genes, reduces cytokine release and inhibits immune‑cell recruitment. Its high first‑pass metabolism limits systemic exposure.
Benefits and advantages
Used in respiratory‑inflammation research, gastrointestinal‑inflammation modelling, corticosteroid‑receptor binding studies, aerosol‑formulation development, inflammatory‑pathway assays and comparative glucocorticoid potency testing.
Side effects and risks
Risks include adrenal suppression, oral candidiasis (in inhaled use), dysphonia, systemic glucocorticoid effects at high doses and local irritation. Handle using steroid‑active compound precautions.
Datasheet
| Molecular Formula | C25H34O6 |
|---|---|
| Molecular Weight | 430.5 g/mol |
| CAS Number | 51333-22-3 |
| Storage Condition | Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place. |
| Solubility | Practically insoluble in water |
| Purity | Purity information is available upon request (COA). |
| Synonym | budesonide; Pulmicort; 51333-22-3; Rhinocort; Entocort |
| IUPAC/Chemical Name | (1S,2S,4R,8S,9S,11S,12S,13R)-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-6-propyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one |
| InChl Key | VOVIALXJUBGFJZ-KWVAZRHASA-N |
| InChl Code | InChI=1S/C25H34O6/c1-4-5-21-30-20-11-17-16-7-6-14-10-15(27)8-9-23(14,2)22(16)18(28)12-24(17,3)25(20,31-21)19(29)13-26/h8-10,16-18,20-22,26,28H,4-7,11-13H2,1-3H3/t16-,17-,18-,20+,21?,22+,23-,24-,25+/m0/s1 |
| References |
3D Conformer.
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