BUCILLAMINE
Bucillamine is a thiol antioxidant and DMARD used in rheumatoid arthritis. Benefits include reduced inflammation. Side effects include rash, hepatotoxicity, and proteinuria. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of action
Bucillamine is a thiolcontaining cysteine derivative with strong antioxidant and immunomodulatory properties. It donates thiol groups, enhances glutathione recycling, scavenges reactive oxygen species and modulates inflammatory signalling pathways. It also acts as a diseasemodifying antirheumatic agent (DMARD).
Benefits and advantages
Used in oxidativestress studies, glutathionemetabolism research, redoxbiology modelling, autoimmunedisease investigations, rheumatology drugdevelopment and thiolreactivity assays.
Side effects and risks
Risks include rash, proteinuria, agranulocytosis, hepatic enzyme changes and hypersensitivity reactions. Handle under thiolreactivecompound safety controls.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C7H13NO3S2 |
|---|---|
| Molecular Weight | 223.3 g/mol |
| CAS Number | 65002-17-7 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | bucillamine; 65002-17-7; Tiobutarit; Bucilamina; Bucilant |
| IUPAC/Chemical Name | (2R)-2-[(2-methyl-2-sulfanylpropanoyl)amino]-3-sulfanylpropanoic acid |
| InChl Key | VUAFHZCUKUDDBC-BYPYZUCNSA-N |
| InChl Code | InChI=1S/C7H13NO3S2/c1-7(2,13)6(11)8-4(3-12)5(9)10/h4,12-13H,3H2,1-2H3,(H,8,11)(H,9,10)/t4-/m0/s1 |
| References |
3D Conformer.
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