BUCILLAMINE
Bucillamine is a thiol antioxidant and DMARD used in rheumatoid arthritis. Benefits include reduced inflammation. Side effects include rash, hepatotoxicity, and proteinuria.
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Product Description
Mechanism of action
Bucillamine is a thiol‑containing cysteine derivative with strong antioxidant and immunomodulatory properties. It donates thiol groups, enhances glutathione recycling, scavenges reactive oxygen species and modulates inflammatory signalling pathways. It also acts as a disease‑modifying antirheumatic agent (DMARD).
Benefits and advantages
Used in oxidative‑stress studies, glutathione‑metabolism research, redox‑biology modelling, autoimmune‑disease investigations, rheumatology drug‑development and thiol‑reactivity assays.
Side effects and risks
Risks include rash, proteinuria, agranulocytosis, hepatic enzyme changes and hypersensitivity reactions. Handle under thiol‑reactive‑compound safety controls.
Datasheet
| Molecular Formula | C7H13NO3S2 |
|---|---|
| Molecular Weight | 223.3 g/mol |
| CAS Number | 65002-17-7 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | bucillamine; 65002-17-7; Tiobutarit; Bucilamina; Bucilant |
| IUPAC/Chemical Name | (2R)-2-[(2-methyl-2-sulfanylpropanoyl)amino]-3-sulfanylpropanoic acid |
| InChl Key | VUAFHZCUKUDDBC-BYPYZUCNSA-N |
| InChl Code | InChI=1S/C7H13NO3S2/c1-7(2,13)6(11)8-4(3-12)5(9)10/h4,12-13H,3H2,1-2H3,(H,8,11)(H,9,10)/t4-/m0/s1 |
| References |
3D Conformer.
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