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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Product Description
Mechanism of action
Bicuculline is a competitive antagonist of GABA_A receptors, particularly at GABA-binding sites. By blocking inhibitory GABAergic signalling, it increases neuronal excitability and is widely used to induce epileptiform activity in experimental models. Bicuculline also inhibits small-conductance calcium-activated potassium (SK) channels at higher concentrations.
Benefits and advantages
Essential in neuroscience research, seizure modelling, synaptic-inhibition studies, GABA_A-receptor mapping, network-excitability experiments and screening of anticonvulsant agents. A gold-standard antagonist for dissecting inhibitory signalling mechanisms.
Side effects and risks
Risks include marked convulsant activity, neurotoxicity, respiratory distress and CNS hyperexcitability. Handle under strict neuroactive-compound precautions with controlled dosing.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C20H17NO6 |
|---|---|
| Molecular Weight | 367.4 g/mol |
| CAS Number | 485-49-4 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | bicuculline; 485-49-4; d-Bicuculline; Bicculine; Bicucullin |
| IUPAC/Chemical Name | (6R)-6-[(5S)-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-6H-furo[3,4-g][1,3]benzodioxol-8-one |
| InChl Key | IYGYMKDQCDOMRE-ZWKOTPCHSA-N |
| InChl Code | InChI=1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1 |
| References |
3D Conformer.
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