BEZLOTOXUMAB

Bezlotoxumab is a monoclonal antibody binding C. difficile toxin B, reducing recurrence risk. Side effects include nausea, fever, and infusion reactions. Only GMP materials will be supplied, logistics all according to GDP.

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Product Description


Mechanism of action

Bezlotoxumab is a fully human monoclonal antibody that binds and neutralises *Clostridioides difficile* toxin B. It prevents toxinmediated cell rounding, cytoskeletal disruption and epithelial damage by blocking toxin interaction with hostcell receptors. Its mechanism targets recurrence rather than acute infection control.

Benefits and advantages

Used in microbiology research, toxinhost interaction studies, neutralisingantibody development, gastrointestinal pathophysiology modelling and C. difficile recurrenceprevention investigations. A key tool for studying toxinmediated colonic injury.

Side effects and risks

Risks include infusion reactions, hypersensitivity, heartfailure exacerbation in predisposed individuals and mild GI effects. Handle under biologicagent containment with temperaturecontrolled storage.

Only GMP materials will be supplied, logistics all according to GDP.

Datasheet


Molecular Weight

g/mol

CAS Number

1246264-45-8

Storage Condition

Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light.

Solubility

Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance.

Purity

Purity information is available upon request (COA).

IUPAC/Chemical Name

N/A human monoclonal antibody

References

https://pubchem.ncbi.nlm.nih.gov/#query=1246264-45-8;

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