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Product Description
Mechanism of action
Aprindine is a class Ib antiarrhythmic agent that blocks voltage‑gated sodium channels in cardiac tissue. By stabilising the inactivated state of Naᵥ channels, aprindine reduces automaticity and suppresses premature ventricular contractions. It also exhibits mild local anaesthetic–like effects.
Benefits and advantages
Used in electrophysiology research, arrhythmia mechanism studies, sodium‑channel pharmacology, and investigational cardiac conduction modelling. Valuable for testing channel‑blocking potency and electrophysiological signatures.
Side effects and risks
Possible proarrhythmia, CNS effects, visual disturbances, hypotension, and conduction abnormalities. Requires cardiac‑active laboratory precautions.
Datasheet
| Molecular Formula | C22H30N2 |
|---|---|
| Molecular Weight | 322.5 g/mol |
| CAS Number | 37640-71-4 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | 7.82e-03 g/L |
| Purity | Purity information is available upon request (COA). |
| Synonym | APRINDINE; 37640-71-4; Aprindina; Aprindinum; COMPOUND 99170 |
| IUPAC/Chemical Name | N'-(2,3-dihydro-1H-inden-2-yl)-N,N-diethyl-N'-phenylpropane-1,3-diamine |
| InChl Key | NZLBHDRPUJLHCE-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C22H30N2/c1-3-23(4-2)15-10-16-24(21-13-6-5-7-14-21)22-17-19-11-8-9-12-20(19)18-22/h5-9,11-14,22H,3-4,10,15-18H2,1-2H3 |
| References |
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