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Product Description
Mechanism of action
Antazoline sulfate is a salt form of antazoline, a first‑generation H₁‑histamine receptor antagonist. It acts by competitively blocking histamine at H₁ receptors in vascular smooth muscle and mucosal tissues, thereby reducing vasodilation, permeability, and allergic inflammatory reactions. The sulfate salt significantly improves aqueous solubility, allowing rapid onset in ophthalmic and intranasal research models.
Benefits and advantages
Used extensively in ocular allergy studies, mast‑cell mediator research, and short‑acting antihistamine comparisons. The increased solubility profile makes it valuable for evaluating drug transport, permeability, and receptor kinetics in mucosal tissues.
Side effects and risks
Possible local irritation, transient burning, mild sedation, anticholinergic effects, and rare hypersensitivity. Handle using standard PPE due to CNS‑active antihistamine properties.
Datasheet
| Molecular Formula | C17H21N3O4S |
|---|---|
| Molecular Weight | 363.4 g/mol |
| CAS Number | 24359-81-7 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Antazoline Sulfate; 24359-81-7; 1H-Imidazole-2-methanamine, 4,5-dihydro-N-phenyl-N-(phenylmethyl)-, sulfate (1:1); UNII-6T74I07212; ANTAZOLINE SULPHATE |
| IUPAC/Chemical Name | N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline;sulfuric acid |
| InChl Key | UWOSJBSLQYMGDL-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C17H19N3.H2O4S/c1-3-7-15(8-4-1)13-20(14-17-18-11-12-19-17)16-9-5-2-6-10-16;1-5(2,3)4/h1-10H,11-14H2,(H,18,19);(H2,1,2,3,4) |
| References |
3D Conformer.
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