ANAGRELIDE HCL
Anagrelide HCl reduces platelet production by inhibiting megakaryocyte maturation. It is used to treat essential thrombocythemia. Benefits include effective platelet count control. Side effects include headache, palpitations, fluid retention, and potential cardiotoxicity, requiring careful monitoring in patients with heart disease.
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Product Description
Mechanism of action
Anagrelide hydrochloride inhibits PDE3 and suppresses megakaryocyte maturation, thereby reducing platelet production. It also exerts mild vasodilatory and chronotropic cardiac effects due to increased cAMP signalling.
Benefits and advantages
Core compound in studies of thrombopoiesis, platelet regulation and myeloproliferative disorders. Also useful for elucidating PDE3‑related cardiometabolic pathways.
Side effects and risks
Tachycardia, arrhythmias, headaches, fluid retention and risk of cardiomyopathy. Cardiac monitoring is essential.
Datasheet
| Molecular Formula | C10H8Cl3N3O |
|---|---|
| Molecular Weight | 292.5 g/mol |
| CAS Number | 58579-51-4 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | ANAGRELIDE HYDROCHLORIDE; 58579-51-4; Anagrelide HCL; Thromboreductin; Anagrelid hydrochlorid |
| IUPAC/Chemical Name | 6,7-dichloro-3,5-dihydro-1H-imidazo[2,1-b]quinazolin-2-one;hydrochloride |
| InChl Key | TVWRQCIPWUCNMI-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C10H7Cl2N3O.ClH/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7;/h1-2H,3-4H2,(H,13,14,16);1H |
| References |
3D Conformer.
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