AMBUPHYLLINE
Ambuphylline is a combination bronchodilator containing theophylline derivatives that relax bronchial smooth muscle and improve airflow in obstructive airway diseases. Benefits include enhanced breathing capacity. Side effects may include headache, insomnia, tremors, and gastrointestinal upset.
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Product Description
Mechanism of action
Ambuphylline is a xanthine-derived bronchodilator and respiratory stimulant. It inhibits phosphodiesterase enzymes, leading to increased intracellular cyclic AMP in bronchial smooth muscle, relaxation of the airways and improved airflow. It may also enhance diaphragmatic contractility and exert mild central nervous system stimulant effects.
Benefits and advantages
Ambuphylline has been used in the management of obstructive airway diseases and as a component of combination products aimed at improving respiratory function. Its methylxanthine properties provide an alternative or adjunct to beta-agonists and inhaled therapies in selected clinical regimens.
Side effects and risks
Like other methylxanthines, ambuphylline has a narrow therapeutic window. Adverse effects include tachycardia, palpitations, insomnia, tremor, gastrointestinal irritation and, at high levels, arrhythmias or seizures. Therapeutic use requires careful dose control and monitoring for signs of toxicity. Handling of the API should be performed in facilities equipped to manage potent bronchodilators.
Datasheet
| Molecular Formula | C11H19N5O3 |
|---|---|
| Molecular Weight | 269.30 g/mol |
| CAS Number | 5634-34-4 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | AMBUPHYLLINE; Bufylline; 5634-34-4; Butaphyllamine; Theophylline aminoisobutanol |
| IUPAC/Chemical Name | 2-amino-2-methylpropan-1-ol;1,3-dimethyl-7H-purine-2,6-dione |
| InChl Key | SEIRRUDMPNNSCY-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C7H8N4O2.C4H11NO/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;1-4(2,5)3-6/h3H,1-2H3,(H,8,9);6H,3,5H2,1-2H3 |
| References |
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