AMBROXOL HCL
Ambroxol hydrochloride is a mucolytic agent that enhances mucus clearance and lung function. It is used in respiratory disorders with thick secretions. Benefits include improved expectoration and reduced coughing. Side effects include nausea, dry mouth, and mild gastrointestinal issues.
About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of action
Ambroxol hydrochloride is a mucolytic and expectorant agent. It acts by depolymerising mucopolysaccharide fibres and altering the structure of bronchial mucus, thereby reducing viscosity and improving mucus transport. Ambroxol also stimulates the production and release of pulmonary surfactant and enhances ciliary activity in the respiratory epithelium.
Benefits and advantages
Through its combined effects on mucus rheology and mucociliary clearance, ambroxol facilitates expectoration in acute and chronic respiratory conditions associated with abnormal mucus secretion, such as bronchitis and COPD. Its local anaesthetic and antioxidant properties have additionally been explored for relief of sore throat symptoms. The compound has a long history of clinical use and is available in multiple oral and inhaled formulations.
Side effects and risks
Ambroxol is generally well tolerated, with the most common adverse events being mild gastrointestinal upset, nausea or dysgeusia. Rarely, serious cutaneous reactions such as Stevens–Johnson syndrome and toxic epidermal necrolysis have been reported, leading to cautionary labelling in some regions. As an API, ambroxol HCl should be handled with measures to limit dust and dermal exposure.
Professional use only. Supplied exclusively to licensed pharmaceutical manufacturers and institutions.
Datasheet
| Molecular Formula | C13H19Br2ClN2O |
|---|---|
| Molecular Weight | 414.56 g/mol |
| CAS Number | 15942-05-9 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | >56.7 [ug/mL] (The mean of the results at pH 7.4) |
| Purity | Purity information is available upon request (COA). |
| Synonym | 15942-05-9; DTXSID60936098; 4-(((2-Amino-3,5-dibromophenyl)methyl)amino)cyclohexan-1-ol–hydrogen chloride (1/1); 4-{[(2-Amino-3,5-dibromophenyl)methyl]amino}cyclohexan-1-ol–hydrogen chloride (1/1); RefChem:1069610 |
| IUPAC/Chemical Name | 4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol;hydrochloride |
| InChl Key | QNVKOSLOVOTXKF-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C13H18Br2N2O.ClH/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10;/h5-6,10-11,17-18H,1-4,7,16H2;1H |
| References |
3D Conformer.
(Click, turn or enlarge)
Download our GMP API Product List.
MedicaPharma is an EU-based supplier of GMP-certified APIs that serves leading healthcare institutions and research organizations.
Click here to download our full API product list.
