ADENOSINE
Adenosine is an endogenous nucleoside that slows atrioventricular nodal conduction via activation of A1 receptors. Clinically, it is used for acute termination of supraventricular tachycardia. Benefits include rapid onset and an extremely short half-life. Side effects are transient and may include flushing, chest discomfort, dyspnea, or brief arrhythmias, all resolving within seconds.
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Product Description
Mechanism of action
Adenosine is an endogenous purine nucleoside involved in energy transfer and signalling. Pharmacologically, adenosine activates A1, A2A, A2B and A3 adenosine receptors. Intravenous bolus administration transiently blocks atrioventricular (AV) nodal conduction, which is exploited for termination of certain supraventricular tachycardias and for diagnostic stress testing in cardiology.
Benefits and advantages
Because of its extremely short half‑life in the circulation, adenosine’s effects are rapid in onset and brief, allowing fine control during diagnostic or interventional procedures. It also serves as a reference agonist in receptor pharmacology and as a substrate or standard in biochemical assays.
Side effects and risks
Transient flushing, chest discomfort, dyspnoea and a sense of impending doom are common during therapeutic bolus administration. More serious risks include prolonged AV block, bronchospasm in asthmatic patients and hypotension. In the context of raw‑material handling, adenosine should be processed under standard pharmaceutical safety measures.
Professional use only. Supplied exclusively to licensed manufacturers and institutions.
Datasheet
| Molecular Formula | C10H13N5O4 |
|---|---|
| Molecular Weight | 267.24 g/mol |
| CAS Number | 58-61-7 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Water solubility increases by warming and lowering the pH |
| Purity | Purity information is available upon request (COA). |
| Synonym | adenosine; 58-61-7; Adenocard; Adenoscan; Adenine riboside |
| IUPAC/Chemical Name | (2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol |
| InChl Key | OIRDTQYFTABQOQ-KQYNXXCUSA-N |
| InChl Code | InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1 |
| References |
3D Conformer.
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