ACITRETIN
Acitretin is a systemic retinoid related to vitamin A and is used in dermatological research involving keratinocyte differentiation, cornification and retinoid receptor pathways. Potential risks include dry skin and mucosa, liver enzyme changes, lipid changes and strong teratogenic potential. Only GMP materials will be supplied, logistics all according to GDP.
About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Acitretin is a systemic retinoid related to vitamin A. It influences nuclear retinoid receptor signalling and helps regulate gene transcription involved in keratinocyte proliferation, differentiation and cornification.
Benefits and Advantages
Acitretin is used in dermatological pharmaceutical research, retinoid pathway studies and development work involving disorders of keratinisation. Its defined retinoid activity makes it useful for evaluating epidermal differentiation, formulation behaviour and stability of retinoid-containing products.
Side Effects and Risks
Known risks of systemic retinoids include mucocutaneous dryness, cheilitis, elevated liver enzymes, lipid changes, skeletal effects and strong teratogenic potential. Strict professional handling, documentation and regulatory controls are required for any development or supply activity.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C21H26O3 |
|---|---|
| Molecular Weight | 326.43 g/mol |
| CAS Number | 55079-83-9 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Soluble in DMSO and ethanol; limited aqueous solubility. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Acitretin; Ro 10-1670; Etretin; 9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid |
| IUPAC/Chemical Name | (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid |
| InChl Key | IHUNBGSDBOWDMA-AQFIFDHZSA-N |
| InChl Code | InChI=1S/C21H26O3/c1-14(8-7-9-15(2)12-21(22)23)10-11-19-16(3)13-20(24-6)18(5)17(19)4/h7-13H,1-6H3,(H,22,23)/b9-7+,11-10+,14-8+,15-12+ |
| References | https://pubchem.ncbi.nlm.nih.gov/compound/5284513; small-molecule |
3D Conformer.
(Click, turn or enlarge)
Download our GMP API Product List.
MedicaPharma is an EU-based supplier of GMP-certified APIs that serves leading healthcare institutions and research organizations.
Click here to download our full API product list.
