ACIPIMOX
Acipimox is a nicotinic acid derivative that lowers triglycerides by inhibiting lipolysis. Used for dyslipidemia, it improves lipid profiles with fewer flushing effects than niacin. Side effects include mild flushing, headache, GI discomfort, and rare glucose tolerance changes. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of action
Acipimox is a nicotinic acid derivative that acts primarily as an antilipolytic agent. It inhibits hormone sensitive lipase in adipose tissue, reducing the release of free fatty acids into the circulation. This leads to decreased hepatic synthesis of verylowdensity lipoproteins and, consequently, a reduction in plasma triglyceride and, to a lesser extent, cholesterol levels.
Benefits and advantages
Acipimox is used in the management of hyperlipidaemia, particularly hypertriglyceridaemia, and can improve lipoprotein profiles in selected patients. Compared with nicotinic acid, it may have a more favourable flushing profile while retaining beneficial lipidmodifying effects.
Side effects and risks
Common adverse effects include flushing, warmth, pruritus and gastrointestinal discomfort. Changes in glucose tolerance, liver enzymes and uric acid can occur, so caution is advised in patients with diabetes, hepatic disease or gout. As an API, acipimox should be handled under standard precautions for active lipidmodifying agents.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C6H6N2O3 |
|---|---|
| Molecular Weight | 154.12 g/mol |
| CAS Number | 51037-30-0 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | ACIPIMOX; 51037-30-0; Olbetam; Olbemox; 5-methylpyrazine-2-carboxylic acid 4-oxide |
| IUPAC/Chemical Name | 5-methyl-4-oxidopyrazin-4-ium-2-carboxylic acid |
| InChl Key | DJQOOSBJCLSSEY-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C6H6N2O3/c1-4-2-7-5(6(9)10)3-8(4)11/h2-3H,1H3,(H,9,10) |
| References |
3D Conformer.
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