ACETYLMETHIONINE

Acetylmethionine is a derivative of methionine supporting liver detoxification by acting as a methyl donor and antioxidant precursor. Benefits include improved methylation and oxidative protection. Side effects are mild, such as nausea, headache, or digestive discomfort.

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Product Description


Mechanism of action

Acetylmethionine is an acetylated derivative of the essential amino acid L‑methionine. It acts as a source of methionine and, indirectly, of sulfur‑containing metabolites such as cysteine and glutathione, which are involved in methylation reactions and cellular antioxidant defence.

Benefits and advantages

Acetylmethionine offers improved stability and handling compared with free methionine in certain formulations. It has been explored as a hepatoprotective and detoxifying agent, supporting hepatic metabolism and conjugation reactions, and as a nutritional supplement in specialised medical nutrition products.

Side effects and risks

At appropriate doses, acetylmethionine is generally well tolerated, but excessive intake of methionine derivatives can contribute to elevations in homocysteine or acid load. Patients with severe hepatic or metabolic disorders require careful supervision. As an API, it should be manufactured and stored under conditions that prevent degradation and contamination.

Datasheet


Molecular Formula

C7H13NO3S

Molecular Weight

191.25 g/mol

CAS Number

65-82-7

Storage Condition

Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light.

Solubility

Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance.

Purity

Purity information is available upon request (COA).

Synonym

N-Acetyl-L-methionine; 65-82-7; N-Acetylmethionine; Acetyl-L-methionine; Methionamine

IUPAC/Chemical Name

(2S)-2-acetamido-4-methylsulfanylbutanoic acid

InChl Key

XUYPXLNMDZIRQH-LURJTMIESA-N

InChl Code

InChI=1S/C7H13NO3S/c1-5(9)8-6(7(10)11)3-4-12-2/h6H,3-4H2,1-2H3,(H,8,9)(H,10,11)/t6-/m0/s1

References

https://pubchem.ncbi.nlm.nih.gov/compound/448580;

3D Conformer.

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