ACETYLDIGOXIN
Acetyldigoxin is a semisynthetic cardiac glycoside that enhances cardiac output via Na⁺/KATPase inhibition. Used for heart failure and atrial arrhythmias, it offers predictable absorption. Risks include arrhythmias, GI upset, fatigue, and toxicity, especially in renal impairment. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of action
Acetyldigoxin is a semisynthetic derivative of digoxin in which an acetyl group is introduced to modify pharmacokinetic behaviour. Like digoxin, it inhibits the myocardial sodiumpotassium ATPase pump, increasing intracellular calcium and producing a positive inotropic effect while also influencing autonomic tone at the atrioventricular node.
Benefits and advantages
Acetyldigoxin has been used as an alternative oral cardiac glycoside with slightly different absorption and distribution characteristics compared with digoxin. It can be formulated to achieve more predictable plasma levels in some patients and is of interest for comparative pharmacology and generic development.
Side effects and risks
Adverse effects are similar to those of other digitalis glycosides and include nausea, vomiting, anorexia, dizziness, confusion and a spectrum of brady- and tachyarrhythmias that may be lifethreatening. The risk is heightened by renal impairment, electrolyte imbalance or interacting drugs. The raw material should therefore be handled only in specialised facilities with appropriate containment.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C43H66O15 |
|---|---|
| Molecular Weight | 823.0 g/mol |
| CAS Number | 5511-98-8 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | alpha-Acetyldigoxin; 5511-98-8; Acetyldigoxin; Lanatilin; Sandolanid |
| IUPAC/Chemical Name | [(2R,3R,4S,6S)-6-[(2R,3S,4S,6S)-6-[(2R,3S,4S,6R)-6-[[(3S,5R,8R,9S,10S,12R,13S,14S,17R)-12,14-dihydroxy-10,13-dimethyl-17-(5-oxo-2H-furan-3-yl)-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-yl]oxy]-4-hydroxy-2-methyloxan-3-yl]oxy-4-hydroxy-2-methyloxan-3-yl]oxy-3-hydroxy-2-methyloxan-4-yl] acetate |
| InChl Key | HWKJSYYYURVNQU-DXJNJSHLSA-N |
| InChl Code | InChI=1S/C43H66O15/c1-20-38(49)32(55-23(4)44)18-37(52-20)58-40-22(3)54-36(17-31(40)46)57-39-21(2)53-35(16-30(39)45)56-26-9-11-41(5)25(14-26)7-8-28-29(41)15-33(47)42(6)27(10-12-43(28,42)50)24-13-34(48)51-19-24/h13,20-22,25-33,35-40,45-47,49-50H,7-12,14-19H2,1-6H3/t20-,21-,22-,25-,26+,27-,28-,29+,30+,31+,32+,33-,35+,36+,37+,38-,39-,40-,41+,42+,43+/m1/s1 |
| References |
3D Conformer.
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