ACETYLCHOLINE CHLORIDE
Acetylcholine chloride is a direct parasympathomimetic that activates muscarinic and nicotinic receptors. It is mainly used in ophthalmic surgery to induce rapid miosis. Benefits include predictable and fast onset with short duration. Possible side effects include eye inflammation, corneal edema, and temporary visual disturbance, with systemic cholinergic effects being rare. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of action
Acetylcholine chloride is the quaternary ammonium ester of acetic acid and choline and is the prototypical endogenous neurotransmitter at muscarinic and nicotinic receptors. When administered pharmacologically, it stimulates cholinergic receptors in the autonomic nervous system, neuromuscular junction and central nervous system, producing a broad range of parasympathomimetic effects.
Benefits and advantages
Because of its direct agonist activity at cholinergic receptors, acetylcholine chloride is primarily used in research and in specialised ophthalmic procedures to induce rapid miosis. It serves as an important reference compound in pharmacological assays investigating cholinergic transmission and receptor function.
Side effects and risks
Systemic administration produces profound parasympathetic stimulation with bradycardia, hypotension, bronchoconstriction, increased glandular secretion and gastrointestinal hypermotility, and is therefore not used therapeutically outside highly controlled settings. Even with local use, accidental systemic absorption can cause adverse cholinergic reactions. The API should be handled only in laboratories equipped to manage potent cholinergic agents.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C7H16NO2Cl |
|---|---|
| Molecular Weight | 181.66 g/mol |
| CAS Number | 60-31-1 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | >27.2 [ug/mL] (The mean of the results at pH 7.4) |
| Purity | Purity information is available upon request (COA). |
| Synonym | ACETYLCHOLINE CHLORIDE; 60-31-1; Miochol; Chloroacetylcholine; Ovisot |
| IUPAC/Chemical Name | 2-acetyloxyethyl(trimethyl)azanium chloride |
| InChl Key | JUGOREOARAHOCO-UHFFFAOYSA-M |
| InChl Code | InChI=1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1 |
| References |
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