ACECAINIDE HCL
Acecainide hydrochloride is an active metabolite of procainamide that blocks cardiac sodium channels, slowing conduction and stabilizing electrical activity. It is used in the management of arrhythmias. Benefits include predictable pharmacokinetics and effectiveness in rhythm control. Side effects include dizziness, gastrointestinal discomfort, and rare proarrhythmic events, requiring monitoring during therapy.
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Product Description
Mechanism of action
Acecainide hydrochloride (N‑acetylprocainamide) is the major active metabolite of procainamide and functions primarily as a class III antiarrhythmic agent. It prolongs the cardiac action potential and refractory period by blocking potassium channels, thereby slowing repolarisation and reducing the propensity for re‑entrant arrhythmias.
Benefits and advantages
Acecainide can contribute to the overall antiarrhythmic effect of procainamide therapy and is of interest in the development and optimisation of class III antiarrhythmic regimens. Its defined pharmacodynamic profile makes it a useful compound for research into cardiac electrophysiology and drug‑interaction studies.
Side effects and risks
Like other class III agents, acecainide carries a risk of QT‑interval prolongation and torsades de pointes. Additional adverse effects may include hypotension, bradycardia and negative inotropic effects. Use in humans requires careful ECG monitoring and dose adjustment, particularly in patients with renal impairment, as the metabolite is renally cleared. Handling of the raw material should be limited to trained personnel under appropriate safety procedures.
Datasheet
| Molecular Formula | C15H24ClN3O2 |
|---|---|
| Molecular Weight | 313.82 g/mol |
| CAS Number | 34118-92-8 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Acecainide hydrochloride; 34118-92-8; Acecainide HCl; ASL 601; ASL-601 |
| IUPAC/Chemical Name | 4-acetamido-N-[2-(diethylamino)ethyl]benzamide;hydrochloride |
| InChl Key | IYEWBJUCJHKLHD-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C15H23N3O2.ClH/c1-4-18(5-2)11-10-16-15(20)13-6-8-14(9-7-13)17-12(3)19;/h6-9H,4-5,10-11H2,1-3H3,(H,16,20)(H,17,19);1H |
| References |
3D Conformer.
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