ABCIXIMAB
Abciximab is a chimeric monoclonal antibody fragment that inhibits platelet aggregation by irreversibly binding to the glycoprotein IIb/IIIa receptor on platelets. It is used as an adjunctive antithrombotic therapy during percutaneous coronary interventions to reduce the risk of acute ischemic complications. Benefits include potent antiplatelet effects and reduced procedural thrombosis. Main risks include bleeding, thrombocytopenia, and rare allergic reactions, requiring close monitoring.
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Product Description
Mechanism of action
Abciximab is a chimeric monoclonal antibody Fab fragment that targets the platelet glycoprotein IIb/IIIa receptor complex. By blocking this integrin, it prevents fibrinogen and von Willebrand factor from binding to activated platelets, thereby inhibiting platelet aggregation and thrombus formation. It also binds to the vitronectin receptor, which may contribute to its antithrombotic profile.
Benefits and advantages
Abciximab has been extensively used as an adjunctive antiplatelet therapy in high‑risk percutaneous coronary interventions and acute coronary syndromes. Its rapid onset of action and strong inhibition of platelet function make it a powerful tool in interventional cardiology when used in combination with heparin and aspirin.
Side effects and risks
The principal risks are bleeding complications and thrombocytopenia, which may be profound in some patients. Immunogenic reactions, including hypersensitivity and the development of human anti‑chimeric antibodies, can occur, especially upon re‑exposure. Because of these risks, use is restricted to specialised settings with close haemodynamic and laboratory monitoring.
Professional use only. This biological API is intended for use by licensed manufacturers and health‑care institutions.
Datasheet
| Molecular Formula | C2101H3229N551O673S15 |
|---|---|
| Molecular Weight | 47615 g/mol |
| CAS Number | 143653-53-6 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Abciximab; ReoPro; c7E3 Fab; Abcixifiban; 143653-53-6 |
| IUPAC/Chemical Name | Abciximab (chimeric monoclonal antibody Fab fragment targeting glycoprotein IIb/IIIa receptor) |
| References |
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