ALFUZOSINE
Alfuzosine is an alpha1-adrenergic receptor antagonist used in urological pharmacology and alpha-blocker research. It reduces adrenergic smooth-muscle tone in lower urinary tract models. Possible risks include dizziness, headache, fatigue, orthostatic hypotension, syncope and interaction concerns with blood-pressure-lowering agents. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
Alfuzosine is an alpha1-adrenergic receptor antagonist. By blocking alpha1 receptors in smooth muscle, particularly in the lower urinary tract, it reduces adrenergic tone and promotes relaxation of prostate and bladder-neck smooth muscle in relevant pharmacological models.
Benefits and Advantages
The compound is used in pharmaceutical development, receptor-binding research, urological pharmacology and comparative studies of alpha-blocker selectivity. Its established smooth-muscle relaxation profile supports formulation, analytical and quality-control workflows for alpha1-antagonist products.
Side Effects and Risks
Potential risks include dizziness, headache, fatigue, orthostatic hypotension, syncope, palpitations and drug-interaction concerns with other blood-pressure-lowering agents. It should be handled and supplied only within qualified pharmaceutical and regulatory frameworks.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C19H27N5O4 |
|---|---|
| Molecular Weight | 389.45 g/mol |
| CAS Number | 81403-80-7 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Alfuzosin; Alfuzosine; Uroxatral; Xatral; SL-77499 |
| IUPAC/Chemical Name | N-[3-[(4-amino-6,7-dimethoxyquinazolin-2-yl)-methylamino]propyl]oxolane-2-carboxamide |
| InChl Key | WNMJYKCGWZFFKR-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C19H27N5O4/c1-24(8-5-7-21-18(25)14-6-4-9-28-14)19-22-13-11-16(27-3)15(26-2)10-12(13)17(20)23-19/h10-11,14H,4-9H2,1-3H3,(H,21,25)(H2,20,22,23) |
| References | https://pubchem.ncbi.nlm.nih.gov/compound/2092; small-molecule |
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