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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Product Description
Mechanism of Action
Glibenclamide (glyburide) is a sulfonylurea that closes ATP-sensitive potassium (KATP) channels on pancreatic beta cells, triggering depolarization, calcium influx and insulin release.
Benefits and Advantages
Used in KATP-channel studies, insulin-secretion assays, metabolic disorder research and pancreatic beta-cell modelling.
Side Effects and Risks
Hypoglycemia, weight gain and rare hematologic reactions.
Datasheet
| Molecular Formula | C23H28ClN3O5S |
|---|---|
| Molecular Weight | 494.0 g/mol |
| CAS Number | 10238-21-8 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | 2.06e-03 g/L |
| Purity | Purity information is available upon request (COA). |
| Synonym | glyburide; Glibenclamide; 10238-21-8; Glynase; Euglucon |
| IUPAC/Chemical Name | 5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide |
| InChl Key | ZNNLBTZKUZBEKO-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29) |
| References |
3D Conformer.
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