About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Gadoterate meglumine is a macrocyclic ionic gadolinium‑based contrast agent (GBCA) formed by chelation of Gd³⁺ with DOTA (tetraazacyclododecanetetraacetic acid) and neutralization with meglumine. The macrocyclic chelate confers high kinetic and thermodynamic stability, minimizing free gadolinium release while shortening T1 relaxation times in MRI.
Benefits and Advantages
Used in high‑stability MRI contrast studies, CNS and vascular imaging, GBCA safety comparison research and gadolinium‑retention modelling.
Side Effects and Risks
Generally favourable safety profile; risks include mild nausea, injection‑site reactions, rare hypersensitivity and theoretical NSF risk in severe renal disease. Handle with standard GBCA precautions.
Datasheet
| Molecular Formula | C23H42GdN5O13 |
|---|---|
| Molecular Weight | 753.9 g/mol |
| CAS Number | 92943-93-6 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Dotarem; Magnescope; P449; P-449; D-Glucitol, 1-deoxy-1-(methylamino)-, (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetato(4-)-kappan1,kappan4,kappan7,kappan10,kappao1,kappao4,kappao7,kappao10)gadolinate(1-) (1:1) |
| IUPAC/Chemical Name | 2-[4,7-bis(carboxylatomethyl)-10-(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetate;gadolinium(3+);(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol |
| InChl Key | RYHQMKVRYNEBNJ-BMWGJIJESA-K |
| InChl Code | InChI=1S/C16H28N4O8.C7H17NO5.Gd/c21-13(22)9-17-1-2-18(10-14(23)24)5-6-20(12-16(27)28)8-7-19(4-3-17)11-15(25)26;1-8-2-4(10)6(12)7(13)5(11)3-9;/h1-12H2,(H,21,22)(H,23,24)(H,25,26)(H,27,28);4-13H,2-3H2,1H3;/q;;+3/p-3/t;4-,5+,6+,7+;/m.0./s1 |
| References |
3D Conformer.
(Click, turn or enlarge)
Download our GMP API Product List.
MedicaPharma is an EU-based supplier of GMP-certified APIs that serves leading healthcare institutions and research organizations.
Click here to download our full API product list.
