GABOXADOL
Gaboxadol is a GABAA receptor agonist that enhances inhibitory neurotransmission, producing sedative and hypnotic effects. It has been studied for insomnia. Side effects include drowsiness, dizziness, confusion, and potential dependence. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
Gaboxadol (THIP) is a potent GABAA receptor agonist with selectivity for extrasynaptic subunitcontaining receptors, producing sustained tonic inhibitory currents. This distinguishes its sedative and hypnotic profile from benzodiazepines, which primarily enhance synaptic GABAA activity.
Benefits and Advantages
Used in sleepstate regulation research, tonicinhibition modelling, receptorsubtype pharmacology and CNS drugdevelopment assays.
Side Effects and Risks
Risks include drowsiness, dizziness, confusion, altered sleep architecture and, at high doses, respiratory and CNS depression. Handle with CNSdepressant precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C7H10N2O2 |
|---|---|
| Molecular Weight | 140.14 g/mol |
| CAS Number | 64603-91-4 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | gaboxadol; THIP; 64603-91-4; Gaboxadolum; MK-0928 |
| IUPAC/Chemical Name | 4,5,6,7-tetrahydro-[1,2]oxazolo[5,4-c]pyridin-3-one |
| InChl Key | ZXRVKCBLGJOCEE-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C6H8N2O2/c9-6-4-1-2-7-3-5(4)10-8-6/h7H,1-3H2,(H,8,9) |
| References |
3D Conformer.
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